While the whole nation is in lockdown because of the COVID-19 pandemic, gay friends Tet, Alma, Jean, and Marie are at their wits end in trying to find ways to beat boredom. Their lack of work and social activities drive them to be creative in making use of their time: from playing games, discussing their kinky adventures, and holding a beauty pageant at home. Next door, former OFW Pinky deals with her overly horny boyfriend, Dave, who resorts to flirting with neighbors every time she turns his advances down. Barangay Captain Lou Perez takes on the difficult task of appeasing his constituents' cry for more relief goods and apprehending health protocol violators—in fabulous fashion. "Ayuda Babes" and its many colorful characters poke fun at mundane situations amid the pandemic. This comedy of errors uses humor, irony, and exaggeration to expose people's eccentricities, peculiarities, and vices, particularly in the context of contemporary politics and other topical issues.